BPC-157 Peptide Supplier | China GMP Manufacturer & Wholesale – AMP Peptide

BPC-157 (Body Protection Compound-157)

AMP Peptide supplies high-purity BPC-157 as a lyophilized peptide designed for laboratory research applications. Manufactured in GMP-compliant facilities and rigorously tested via HPLC and mass spectrometry, our BPC-157 meets the quality standards demanded by academic institutions, pharmaceutical R&D departments, and biotechnology laboratories worldwide.

For pricing, bulk orders, or technical inquiries, contact us.

Short Product Overview

BPC-157, or Body Protection Compound-157, is a synthetic pentadecapeptide comprising 15 amino acids derived from a protective protein found in human gastric juice. Classified under tissue repair and regenerative research peptides, BPC-157 has been the subject of numerous laboratory investigations exploring its molecular mechanisms and biological activity.

The peptide sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) demonstrates stability in lyophilized form and is widely studied for its interactions with cellular signaling pathways involved in angiogenesis, endothelial cell migration, and tissue remodeling processes.

AMP Peptide manufactures BPC-157 using advanced solid-phase peptide synthesis (SPPS) technology, followed by preparative HPLC purification and rigorous quality control testing. Each batch is accompanied by a Certificate of Analysis (COA) documenting HPLC purity, mass spectrometry identity confirmation, and peptide content. Our manufacturing processes are designed to support the reproducibility requirements of academic and commercial research laboratories.

What Is BPC-157 Peptide?

Discovery and Research Background

BPC-157 was first identified and isolated from human gastric juice protein by researchers investigating cytoprotective factors in the gastrointestinal system. The discovery emerged from studies focused on understanding how the stomach lining maintains structural integrity under physiological stress. The full-length protein was found to contain a stable 15-amino-acid fragment, subsequently designated Body Protection Compound-157, which retained the biological activity of the parent molecule.

Since its identification, BPC-157 has been investigated in hundreds of preclinical studies across multiple research domains, including gastroenterology, orthopedics, wound healing, and soft tissue repair biology.

Peptide Structure and Amino Acid Sequence

BPC-157 is a pentadecapeptide with the following amino acid sequence:

Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

The sequence contains multiple proline residues that contribute to its structural stability and resistance to enzymatic degradation. The molecular structure features a calculated isoelectric point that supports solubility in physiological buffers commonly used in laboratory research.

Peptide Classification

BPC-157 belongs to the class of synthetic peptide analogs derived from naturally occurring gastric proteins. In research contexts, it is categorized under:

• Cytoprotective peptides — investigated for tissue protection mechanisms
• Angiogenic peptides — studied for vascular growth factor modulation
• Regenerative peptides — explored in cellular repair and remodeling models
• Research peptides — supplied exclusively for laboratory investigation

Laboratory Applications

BPC-157 is widely utilized in preclinical research settings for:

• In vitro cell culture studies examining cell migration and proliferation
• In vivo animal models investigating soft tissue recovery
• Molecular biology assays exploring growth factor expression
• Histological analysis of tissue architecture and collagen organization
• Vascular biology research examining endothelial cell behavior

The peptide is supplied as a lyophilized powder for reconstitution in laboratory-grade solvents prior to experimental use.

Molecular Characteristics

Research Overview

BPC-157 has been investigated in numerous laboratory models exploring tissue repair mechanisms at the molecular and cellular level.

Key Areas of Laboratory Investigation

• Angiogenesis studies: BPC-157 has been shown to upregulate vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) expression in experimental models, promoting new blood vessel formation in damaged tissue environments.
• Cell migration assays: Research models demonstrate that BPC-157 enhances endothelial cell migration through modulation of actin cytoskeletal dynamics, an effect mediated in part through the FAK-paxillin signaling pathway.
• Collagen synthesis: Laboratory studies indicate that BPC-157 influences collagen type I and type III deposition patterns, affecting the extracellular matrix remodeling process.
• Growth factor regulation: Investigations have explored BPC-157’s effects on the expression of multiple growth factors, including TGF-β, PDGF, and EGF, in various tissue types.
• Inflammatory mediator modulation: Research suggests BPC-157 may modulate the expression of pro-inflammatory cytokines such as TNF-α and IL-6 in controlled experimental conditions.

Receptor and Signaling Pathway Research

Current understanding of BPC-157’s molecular mechanism involves interactions with multiple signaling cascades:

• FAK (Focal Adhesion Kinase) pathway: Phosphorylation dynamics influenced by BPC-157 in cell adhesion studies
• PI3K/Akt signaling: Reported activation in cell survival assays
• NOS (Nitric Oxide Synthase) system: Modulation of NO production in endothelial cell models
• MAPK/ERK pathway: Effects on cell proliferation signaling investigated in vitro
• HSP70 (Heat Shock Protein 70): Upregulation observed in stress response models

Biological Models Studied

BPC-157 has been examined in:

• Rodent models of gastrointestinal injury
• Tendon and ligament repair studies
• Muscle regeneration experiments
• Corneal wound healing models
• Skin incision and burn wound models
• Bone fracture healing investigations
• Soft tissue adhesion research

How Does BPC-157 Work

The molecular mechanisms of BPC-157 remain an active area of research investigation. Based on published laboratory studies, several key pathways have been identified.

Receptor Interactions

BPC-157 does not appear to bind to a single classical receptor but rather exerts its effects through a multi-modal mechanism involving:

Growth Factor Receptor Modulation: BPC-157 has been observed to upregulate the expression of VEGF and its receptors (VEGFR-1 and VEGFR-2) in endothelial cell cultures. This upregulation is associated with enhanced angiogenic signaling in laboratory models.

Integrin-Mediated Signaling: Research indicates that BPC-157 may influence integrin expression patterns on cell surfaces, affecting cell-matrix adhesion and downstream signaling through focal adhesion complexes. This mechanism is particularly relevant in cell migration studies.

Cytoskeletal Dynamics

At the cellular level, BPC-157 has been shown to influence actin reorganization. Studies using fluorescence microscopy have demonstrated that BPC-157-treated cells exhibit altered F-actin distribution patterns consistent with enhanced migratory capacity. The FAK-paxillin signaling axis appears to play a central role in this process, with phosphorylation events occurring within minutes of peptide exposure in cell culture models.

Nitric Oxide Pathway

The nitric oxide (NO) system represents another significant axis of BPC-157 research activity. Laboratory experiments have shown that BPC-157 can modulate endothelial nitric oxide synthase (eNOS) activity, leading to changes in NO production levels. This effect is believed to contribute to the peptide’s observed influence on vascular dynamics in experimental models.

Angiogenic Signaling Cascade

BPC-157’s pro-angiogenic effects in research models are thought to involve:

1. VEGF upregulation → increased receptor activation 2. eNOS activation → NO production → vasodilation 3. MMP (matrix metalloproteinase) modulation → extracellular matrix remodeling 4. Endothelial cell proliferation → capillary formation 5. Pericyte recruitment → vessel stabilization

Molecular Pathway Summary

Manufacturing Process

AMP Peptide produces BPC-157 through a controlled manufacturing process designed to ensure batch-to-batch consistency and high purity.

Step 1: Solid-Phase Peptide Synthesis (SPPS)

BPC-157 is synthesized using Fmoc-based solid-phase peptide synthesis chemistry. The 15-amino-acid sequence is assembled sequentially on a resin support, with each amino acid addition verified through coupling efficiency monitoring. The process is automated on advanced peptide synthesizers operating under controlled environmental conditions.

Step 2: Cleavage and Deprotection

Following sequence completion, the peptide is cleaved from the resin, and side-chain protecting groups are removed using trifluoroacetic acid (TFA)-based cleavage cocktails. The crude peptide is then precipitated and washed to remove residual reagents.

Step 3: Preparative HPLC Purification

The crude BPC-157 undergoes purification via preparative reverse-phase high-performance liquid chromatography (RP-HPLC). This process separates the target peptide from truncated sequences, deletion peptides, and other synthesis by-products, achieving the target purity specification of ≥98%.

Step 4: Mass Spectrometry Confirmation

Purified BPC-157 is analyzed by electrospray ionization mass spectrometry (ESI-MS) to confirm molecular identity. The measured molecular weight is compared against the theoretical value of 1419.55 g/mol.

Step 5: Lyophilization

The purified peptide solution is frozen and lyophilized (freeze-dried) to produce a stable, white lyophilized powder. This process removes water content while preserving peptide integrity.

Step 6: Quality Control Testing

Each production batch undergoes comprehensive QC testing as described in the Quality Control section below.

Step 7: Packaging

Lyophilized BPC-157 is packaged under controlled conditions in sterile, graduated vials or bulk containers, depending on the order specification.

Why Purity Matters

Peptide purity is a critical parameter in laboratory research. Impurities — including truncated sequences, oxidation products, or residual solvents — can produce confounding results in biological assays. At AMP Peptide, we maintain ≥98% purity to support the data integrity requirements of published research.

Why Stability Matters

Lyophilized peptide stability directly affects experimental reproducibility. Our manufacturing process includes optimization of counterion composition, residual moisture control, and packaging under inert conditions to maximize shelf life and reconstitution quality.

Product Specifications

Quality Control

AMP Peptide implements a comprehensive quality control protocol for every BPC-157 batch.

HPLC Analysis

Reverse-phase HPLC is performed on each batch to determine purity. The chromatogram is analyzed for main peak purity, and any impurity peaks above 0.5% are identified and quantified. Our specification threshold of ≥98% ensures that the target peptide constitutes the vast majority of the product.

Mass Spectrometry (ESI-MS)

Electrospray ionization mass spectrometry provides molecular weight confirmation. The measured mass is compared against the calculated monoisotopic mass. A deviation of less than ±1 Da is required for batch release.

Certificate of Analysis (COA)

Each shipment includes a COA documenting:

• HPLC purity percentage
• HPLC chromatogram (available upon request)
• ESI-MS confirmation spectrum
• Peptide content (net peptide weight percentage)
• Appearance and physical description
• Storage and handling recommendations

Additional Testing Available

Upon request, the following additional analyses can be performed:

• Amino Acid Analysis (AAA): Quantitative amino acid composition verification
• Water Content (Karl Fischer): Residual moisture determination
• Endotoxin Testing: LAL assay (suitable for certain research applications)
• Peptide Purity Profiling: Extended HPLC gradient methods
• Mass Spectrometry (MS/MS): Sequence confirmation via fragmentation analysis

Batch Traceability

All BPC-157 batches are assigned unique lot numbers with full manufacturing records maintained for traceability. This ensures complete transparency from raw material sourcing through final product release.

Available Specifications & Pricing

Wholesale and Bulk Orders

AMP Peptide offers competitive pricing for institutional and bulk orders. Each box contains 10 vials at the specified dosage. For orders exceeding standard specifications or requiring customized packaging, please contact us for a tailored quotation.

OEM and Private Label

For qualified B2B partners, we offer OEM and private label services, including custom vial labeling, packaging design, and dedicated batch production.

Applications in Research

Molecular Research

BPC-157 is widely employed in molecular biology investigations examining cell signaling pathways, gene expression regulation, and protein-protein interactions. Researchers utilize the peptide in Western blotting, ELISA, and PCR-based assays to study the downstream effects of peptide treatment on cellular machinery. The peptide’s influence on growth factor expression, particularly VEGF and bFGF, makes it a valuable tool in angiogenesis research.

Cell Studies

In cell culture models, BPC-157 has been studied for its effects on:

• Fibroblast proliferation and migration: Wound closure assays (scratch test models)
• Endothelial cell tube formation: In vitro angiogenesis assays
• Keratinocyte differentiation: Epithelial cell culture models
• Tenocyte activity: Tendon cell research applications
• Myoblast differentiation: Muscle cell culture studies
• Osteoblast function: Bone cell experimental models

Metabolic Studies

BPC-157 has been investigated in research examining cellular energy metabolism, nitric oxide production, and oxidative stress responses. Laboratory studies have explored the peptide’s effects on mitochondrial function and ATP production in various cell types.

Laboratory Investigations

Key experimental areas include:

• Wound healing models: Full-thickness excision and incision models in rodents
• Tendon repair studies: Achilles tendon and patellar tendon experimental models
• Muscle regeneration research: Crush injury and laceration models
• Gastrointestinal integrity studies: Experimental colitis and gastric lesion models
• Vascular research: Aortic ring assays and CAM (chick chorioallantoic membrane) models
• Neurological investigations: Peripheral nerve regeneration research
• Ophthalmological research: Corneal wound healing models

Peptide Science Research

As a synthetic peptide, BPC-157 is also studied in the context of peptide chemistry, including:

• Structure-activity relationship (SAR) studies
• Peptide stability and degradation kinetics
• Formulation development for research-grade peptides
• Comparative analysis of peptide delivery systems

Why Choose AMP Peptide

GMP-Compliant Manufacturing

Our production facilities operate under Good Manufacturing Practice guidelines, ensuring consistent quality across all batches. Manufacturing processes are documented and controlled to maintain reproducibility.

Rigorous Quality Testing

Every batch undergoes HPLC purity analysis, mass spectrometry identity confirmation, and net peptide content determination before release. Third-party testing is available upon request for institutional buyers.

Global Export Experience

AMP Peptide ships to research institutions, biotechnology companies, and pharmaceutical laboratories worldwide. We maintain expertise in international shipping regulations for research chemicals.

Custom Manufacturing Capabilities

We offer custom synthesis services for researchers requiring modified peptide sequences, specialized purity grades, or specific counterion compositions. Our technical team can discuss project requirements and provide manufacturing feasibility assessments.

Wholesale Supply Capacity

Our production capacity supports institutional and wholesale orders with consistent pricing and reliable lead times. Volume discounts are available for bulk purchases.

Complete Documentation

Each order includes Certificates of Analysis with full analytical data. Additional documentation, including HPLC chromatograms and MS spectra, is provided upon request.

Reliable Delivery

We maintain inventory of standard specifications for rapid order fulfillment. Custom orders are scheduled based on manufacturing timelines, with clear communication throughout the process.

Technical Support

Our scientific team is available to answer technical questions regarding peptide handling, reconstitution, storage, and experimental applications.

Packaging Information

Storage Information

Lyophilized Peptide Storage

BPC-157 in lyophilized (freeze-dried) powder form should be stored at -20°C for long-term preservation. Under these conditions, the peptide remains stable for 24 months or longer.

Short-Term Storage

For peptides in active use, storage at 2-8°C in a desiccated environment is acceptable for up to 30 days. Keep the vial tightly sealed and protected from moisture.

Reconstituted Peptide Storage

Once reconstituted in water, PBS, or saline, BPC-157 solutions should be stored at 2-8°C and used within 7-14 days. For extended use, aliquoting and freezing at -20°C is recommended. Avoid repeated freeze-thaw cycles.

Transportation Requirements

For international shipments, lyophilized peptides are stable at ambient temperatures during transit (typically 3-10 days). Temperature-controlled shipping is available upon request for sensitive research protocols.

Stability Considerations

Key factors affecting BPC-157 stability:

• Temperature: Elevated temperatures accelerate degradation; maintain cold storage
• Moisture: Lyophilized peptide is hygroscopic; minimize exposure to ambient humidity
• pH: Reconstituted solutions should be at pH 4-7 for optimal stability
• Oxidation: Protect from prolonged exposure to atmospheric oxygen
• Light: While BPC-157 is not highly photosensitive, storage in darkness is recommended

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FAQ Section

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For a complete overview of all available research peptides and pricing, visit our complete peptide product catalog.

What is BPC-157 peptide?

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide comprising 15 amino acids. It was originally derived from a protective protein identified in human gastric juice. The peptide has been the subject of extensive laboratory research investigating its molecular mechanisms related to angiogenesis, cell migration, and tissue repair processes. It is supplied as a lyophilized powder for reconstitution and use in controlled research settings.

What is the amino acid sequence of BPC-157?

The complete amino acid sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. This 15-amino-acid sequence contains multiple proline residues that contribute to its structural stability and resistance to enzymatic degradation in experimental conditions.

Is BPC-157 suitable for laboratory research?

Yes, BPC-157 is designed and manufactured specifically for laboratory and scientific research purposes. It is widely used in preclinical studies examining angiogenesis, cell migration, collagen synthesis, and tissue repair mechanisms. The peptide is not intended for human consumption or medical use.

How should BPC-157 be stored?

Lyophilized BPC-157 should be stored at -20°C for long-term preservation. For short-term use, storage at 2-8°C in a desiccated environment is acceptable. Once reconstituted, the solution should be kept at 2-8°C and used within 7-14 days. Avoid repeated freeze-thaw cycles.

What purity specifications are available?

Our standard BPC-157 is supplied at ≥98% purity as determined by HPLC analysis. Custom purity specifications are available upon request for specialized research applications requiring higher purity thresholds.

What testing methods are used?

Each batch is tested using reverse-phase HPLC for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular weight identity confirmation. Additional testing options include amino acid analysis, water content determination, endotoxin testing, and MS/MS sequence confirmation.

Is wholesale available?

Yes, AMP Peptide offers wholesale pricing for BPC-157 orders of 1 gram and above. Bulk orders can be customized in terms of packaging, labeling, and documentation. Volume-based pricing is available for institutional and B2B clients.

Can custom packaging be provided?

Yes, we offer OEM and private label services for qualified B2B partners. Custom packaging options include vial labeling, bulk container specifications, and dedicated batch production with customized documentation.

Does AMP Peptide provide COA documents?

Yes, every order includes a Certificate of Analysis documenting HPLC purity, mass spectrometry confirmation, peptide content, and physical description. Additional analytical data, including HPLC chromatograms and MS spectra, is available upon request.

What research applications use BPC-157?

BPC-157 has been investigated in laboratory studies related to angiogenesis, wound healing, tendon repair, muscle regeneration, gastrointestinal integrity, and vascular biology. It is utilized in cell culture assays, animal research models, and molecular biology investigations.

What industries use BPC-157 peptides?

BPC-157 is used in academic research institutions, pharmaceutical R&D laboratories, biotechnology companies, and contract research organizations (CROs) conducting preclinical studies in tissue repair, regenerative medicine, and cellular signaling research.

What shipping methods are available?

We offer standard and express shipping options for domestic and international orders. Cold chain shipping is available for temperature-sensitive research protocols. All shipments comply with applicable regulations for research chemical transportation.

What is the shelf life of BPC-157?

When stored properly at -20°C in lyophilized form, BPC-157 has a shelf life of 24 months or longer. The peptide should be protected from moisture and excessive heat during storage.

Can BPC-157 be used for peptide blending in research?

Yes, BPC-157 is frequently investigated in combination with other peptides in controlled research settings. Common research combinations include BPC-157 with TB-500 for tissue repair studies. Researchers should consult published literature for established research protocols.

Is BPC-157 legal for research purposes?

BPC-157 is supplied exclusively for laboratory research purposes and is not approved for human use. Researchers should verify compliance with local regulations governing the procurement and use of research peptides in their jurisdiction. AMP Peptide provides documentation to support institutional research compliance.

Research Use Disclaimer

This product is supplied exclusively for laboratory and scientific research purposes.

It is not intended for human consumption, medical use, diagnosis, treatment, or disease prevention. BPC-157 has not been evaluated by the FDA or any other regulatory body for safety or efficacy in humans. The product is intended for use by qualified researchers in controlled laboratory settings only.

AMP Peptide makes no claims regarding the therapeutic or medical benefits of BPC-157. All products are manufactured for research purposes and sold with the understanding that the purchaser will use them in compliance with all applicable laws and regulations.